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Slovenska pediatrija 2015; 22: 240-248

Review article


T. Kersnik Levart
Klinični oddelek za nefrologijo, Pediatrična klinika, Univerzitetni klinični center Ljubljana, Ljubljana, Slovenija


In this review article, the author initially defines C3 glomerulopathy and provides new insights into the pathophysiology of this disease. This is followed by a description of the pathohistological and clinical presentation. Recommendations for the diagnostic work-up are reviewed as well as therapeutic options in children with C3 glomerulopathy. Finally, the prognosis in native and transplanted kidneys is discussed.

Key words: C3 glomerulopathy, dense deposit disease, C3 glomerulonephritis, complement, children.

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